How XIAFLEX® is administered

How XIAFLEX^® is administered

XIAFLEX^® (collagenase clostridium histolyticum) is an injection that is given directly into the Dupuytren's cord. You can get treated right in your doctor's office. Please read the XIAFLEX^®Medication Guide before you receive XIAFLEX^® and each time you get an injection.

XIAFLEX^® injection

Injecting XIAFLEX^®

• First, your doctor will clean the area
• The cord that is causing your finger to bend will be injected with a small needle
• Once the injection is over, your doctor will provide a bandage to cover your hand

If you have more than one cord and your specialist thinks it is appropriate, the next cord that you have may be treated with XIAFLEX^® at a later time.

Tip: Limit moving and using the treated finger after the injection. Keep the injected hand elevated until bedtime. Your finger may straighten on its own before you see the doctor, but do not try to push it into a straighter position

Next day follow-up with your hand specialist

• You will return to your doctor for a finger extension about 24 hours after your XIAFLEX^® injection(s). In this part of the procedure, your doctor will carefully unbend your finger to "break" the cord and try to straighten the finger. Many patients feel or hear a popping or cracking sound. (Some say it is like the sound of knuckles cracking.)

Tip: After the finger extension visit, your doctor will give you a splint to wear at night to help keep your finger straight. You may also be shown finger exercises to do at home.

• Follow your doctor's instructions about when you can start doing your normal activities with the injected hand

30-day follow-up with your specialist

• After about 30 days have passed, you should see your doctor for a progress check
• Because individual results will vary, your doctor may suggest repeating the XIAFLEX^® treatment cycle (Steps 1, 2 and 3) up to 3 times for each Dupuytren's cord